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Extra resources for Nаturе Mаgаzinе (17 September 2015)
Finally, when the authors retrained mice on the same task for which spine potentiation had been disrupted, most of the optically shrunken spines reverted to their original potentiated sizes. Together, these results suggest that distinct subsets of synapses are altered in a task-specific way during motor learning and memory formation. In the long quest for the engram, neuro scientists have reached the consensus that the mammalian brain stores different memory traces in different subsets of neurons in specific regions.
B, In the new data set using MTPS, boxplots showing interquartile range of median abundance of statistically significant comparisons between controls (orange), compensated cirrhosis (green) and decompensated cirrhosis (blue) using multiple corrections-adjusted Kruskal–Wallis tests at the family level. The line in the centre shows median. 1 7 S E P T E M B E R 2 0 1 5 | VO L 5 2 5 | N AT U R E | E 1 G2015 Macmillan Publishers Limited. All rights reserved BRIEF COMMUNICATIONS ARISING Therefore, the careful separation of the two groups within cirrhosis, which have different diagnostic criteria and prognoses, and the control of confounders owing to drugs mentioned above, are important for the correct interpretation of these results and to avoid epiphenomena.
Liver Physiol. 307, G951–G957 (2014). Segata, N. et al. Metagenomic biomarker discovery and explanation. Genome Biol. 12, R60 (2011). , Keshavarzian, A. & Mutlu, E. A. Quantitative assessment of the human gut microbiome using multitag pyrosequencing. Chem. Biodivers. 7, 1065–1075 (2010). Zhang, Z. et al. Large-scale survey of gut microbiota associated with MHE via 16S rRNA-based pyrosequencing. Am. J. Gastroenterol. 108, 1601–1611 (2013). Elkrief, L. et al. Diabetes mellitus is an independent prognostic factor for major liver-related outcomes in patients with cirrhosis and chronic hepatitis C.
Nаturе Mаgаzinе (17 September 2015)