By G. W. Richter, Kim Solez
This two-volume set is a finished overview of the "in vivo" results in experimental animals brought about through a number of contributors of the cytokine relatives. The volumes clarify the pharmacological and toxico-pathological impression of such hematopoietic development elements as colony stimulating issue, the unconventional elements IL-11 and stem cellphone elements. Then it summarizes the large spectrum of job of a number of immunostimulatory assays (interleukins IL-1-IL-9) in traditional toxicological assays in addition to effects from transgenic versions. The set additionally good points the inflammatory cytokines (IL-1, TNFa and beta, interfereon-g and TGF-beta) accurately reviewed through specialists within the box. The set experiences the constitution and distribution of the membrane receptors for those development components. It addresses the function of assorted cytokines in illness procedures (malaria, sepsis, and meningitis). Volumes 34A and 34B additionally disguise the scientific adventure with progress elements (interferons and GM-CSF), which in actual fact exhibit that the preclinical info have been predictive and worthy for the clinician. each one quantity of "International evaluation of Experimental Pathology" comprises an index, and every bankruptcy comprises references
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Additional resources for Cytokine-Induced Pathology, Part B : Inflammatory Cytokines, Receptors, and Disease
Inflammatory score after a single intradermal injection of IL-8 or PFS in rats. Comparison between values ± SEM for PFS-injected sites (A, n = 4-8) and values ± SEM for sites injected with 10"9 mol of IL-8 ( · , n = B). tides tested. GRO-a induced an appreciable intradermal neutrophil accumu lation at 10" n mol/site, whereas at 1 0 - 1 0 and especially 10~ 9 mol/site it caused an extremely strong inflammatory reaction (Figs. 4b and 5). IL-8 induced a slightly weaker but still substantial inflammatory reaction (Fig.
The demonstration of the in vivo activity of IL-8 and related neutrophil-activating peptides in man and animals strongly suggests their important role in the pathophysiology of inflammatory diseases. VI. SUMMARY Interleukin-8 is a member of a novel cytokine family and has been found to be an activator and attractant for human neutrophils in vitro. The in vivo activity was tested in experimental animal models by intradermal and intra venous administration of IL-8. Intradermal administration of human IL-8 in rats induces a rapid and concentration-dependent neutrophil infiltration, which peaks 4 hr after IL-8 application.
Waringa, R. A. , Kok, P. T. , and Bruijnzeel, P. L. B. (1991 ). Blood 11, 2694. , Oppenheim,!. J. / Immunol. 139,788. Pathology of Recombinant Human Transforming Growth Factor-ß1 in Rats and Rabbits Timothy G. Terrell Department of Safety Evaluation Genentech, Inc. South San Francisco, California 94080 Peter K. Working Department of Pharmacology and Toxicology Liposome Technologies, Inc. Menlo Park, California 94025 C. Paul Chow and James D. , South San Francisco, California 94080 I. Introduction II.
Cytokine-Induced Pathology, Part B : Inflammatory Cytokines, Receptors, and Disease by G. W. Richter, Kim Solez