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Fat issues in the form of small droplets into the enlarging lumen of the gland. These droplets consist of sm all round fat particles and larger confluent particles (Fig. 18). The Golgi field also increases in size, but always remains free from secretion products. The casein synthesis charaderistic for lactogenesis does not occur after experimental treatment with oestrogen and progesterone. 3· R. BÄSSLEH: Fig. 18. Partial reproduction of the wall of a glandular alveolus after treatment of a castrated rat with oestrogen for 20 days.

Transplants of the Anterior Lobe of the Pituitary When homologous transplants of the pituitary of 60-day-old fern ale mice were implanted into the inguinal region of mice of similar age, some of whom had been castrated, the non-ovarectomized animals showed lobulo-alveolar growth 120 days later around the transplant. BARDIN, LIEBELT, and LIEBELT (1962) had found some formation of buds in castrated mice. This is a direct mammogenic impulse towards local growth. When transplantation into the anterior chamber of the eye was carried out (BARDIN and LIEBELT, 1964), the mammary glands reacted with lobulo-alveolar proliferation.

The results indicate the activity of lysosomes in areas of focal cytoplasmic degradation in the glandular and macrophage-like cells. Adenosine triphosphatase is localized exdusively in the mesenchymal parts of the mammary gland, especially in blood-vessels, nerves, and lymph nodes. It shows differences of reactions only when there is congestion of milk with increased fluid outflow. MEIER-RuGE (1966) and HOLZNER and KAUFMANN (1965) have described in carcinoma of the breast rises of intensity of ATP-ase, whereby a kind of negative picture of the tumour tissue is created.

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