Download e-book for kindle: Combinatorial Chemistry on Solid Supports by Nicole Jung, Matthias Wiehn, Stefan Bräse (auth.), Stefan

February 2, 2018 | Chemistry | By admin | 0 Comments

By Nicole Jung, Matthias Wiehn, Stefan Bräse (auth.), Stefan Bräse (eds.)

ISBN-10: 3540725091

ISBN-13: 9783540725091

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"This e-book, written by way of a world team of popular specialists of their respective box, covers contemporary advances in very important subject matters relating to combinatorial chemistry on stable helps. … it will likely be an invaluable addition to the evaluation literature and will be of curiosity to an important section of co-workers operating in SPOC." (Rolando Perez-Pineiro and Hicham Fenniri, JACS, Vol. one hundred thirty (13), 2008)

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Domino Heck Diels–Alder reaction shown in Scheme 46, compound 325) are possible in this context leading to further diversification [236, 237]. g. ) via a diazonium intermediate and a nucleophilic ortho-substituent. While the diazonium group is lost as dinitrogen upon cleavage from the resin, a suitable nucleophilic ortho-substituent favors cyclization to give heterocyclic structures 319. Benzotriazoles, for example, are accessible from o-aminoaryl-substituted triazenes after a two-step reaction sequence: a nucleophilic displacement followed by cleavage/heterocyclization [239].

G. ) via a diazonium intermediate and a nucleophilic ortho-substituent. While the diazonium group is lost as dinitrogen upon cleavage from the resin, a suitable nucleophilic ortho-substituent favors cyclization to give heterocyclic structures 319. Benzotriazoles, for example, are accessible from o-aminoaryl-substituted triazenes after a two-step reaction sequence: a nucleophilic displacement followed by cleavage/heterocyclization [239]. Starting from commercially available 2-fluoro-5-nitroaniline, this aniline was diazotized and coupled to benzylaminomethylpolystyrene to give the immobilized triazene 328 (R = NO2 , X = F, equivalent to Sanger reagent).

Scheme 61 Traceless cleavage from thioether resins with SmI2 To our knowledge there is only one publication concerning cleavage of thioether linkers via attack of carbon nucleophiles. The approach developed by Hennequin et al. in 1999 describes the utility of deprotonated oxindol ring systems 426 for the nucleophilic displacement of the solid support 425 [279]. The substrate-resin complex has been synthesized very easily by coupling of a quinazoline core 424 to Merrifield resin (1) in the presence of P4 S10 .

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Combinatorial Chemistry on Solid Supports by Nicole Jung, Matthias Wiehn, Stefan Bräse (auth.), Stefan Bräse (eds.)


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