Combination Cancer Therapy: Modulators and Potentiators - download pdf or read online

February 2, 2018 | Oncology | By admin | 0 Comments

By Gary K. Schwartz

ISBN-10: 1588292002

ISBN-13: 9781588292001

Specialist physician-scientists and clinicians assessment these mixtures of novel objective brokers vintage chemotherapies that carry the main promise for the way forward for clinical oncology, and element their optimum series, pharmacokinetic interactions, and interplay with downstream mobile signs. The mixtures run the gamut of precise cures opposed to mobile floor receptors (EGF-R and HER2), the mobile cycle (the CDKs), sign transduction occasions (PKC and NF-kB), apoptosis (bcl-2), in addition to targeted cures in ovarian melanoma, hematologic ailments, and breast melanoma. The authors emphasize novel translational techniques which are speedily relocating from the laboratory bench best to the patient's bedside for the longer term remedies in melanoma treatment.

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Additional info for Combination Cancer Therapy: Modulators and Potentiators (Cancer Drug Discovery and Development)

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Proc Am Soc Clin Oncol 2001;20:A831. 104. Townsley C, Major P, Siu LL, et al. Phase II study of OSI-774 in patients with metastatic colorectal cancer. Eur J Cancer 2002;38, Suppl 7:57 (abstract 179). 105. Torrance CJ, Jackson PE, Montgomery E, et al. Combinatorial chemoprevention of intestinal neoplasia. Nature Med 2000;6:1024–1028. 106. Hidalgo M, Erlichman C, Rowinsky EK, et al. Phase 1 trial of EKB-569, an irreversible inhibitor of the epidermal growth factor receptor (EGFR), in patients with advanced solid tumors.

108. Rusnak DW, Lackey K, Aflleck K, et al. The effects of the novel, reversible Epidermal Growth Factor Receptor/ErbB-2 tyrosine kinase inhibitor , GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther 2001;1:85–94. 109. Fry DW, Bridges AJ, Denny WA, et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. Proc Natl Acad Sci USA 1998;95:12,022–12,027. 110. Zinner RG, Nemunaitis JJ, Donato NJ, et al.

Kim ES, Mauer AM, Fossella FV, et al. A phase II study of Erbitux (IMC-C225), an epidermal growth factor receptor (EGFR) blocking antibody, in combination with docetaxel in chemotherapy refractory/resistant patients with advanced non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 2002;21:A1168. 80. Robert F, Ezekiel MP, Spencer SA, et al. Phase I study of anti-epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer.

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Combination Cancer Therapy: Modulators and Potentiators (Cancer Drug Discovery and Development) by Gary K. Schwartz

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