Z. M. Bacq's Chemical Transmission of Nerve Impulses. A Historical Sketch PDF

February 1, 2018 | General Reference | By admin | 0 Comments

By Z. M. Bacq

ISBN-10: 0080205127

ISBN-13: 9780080205120

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Extra info for Chemical Transmission of Nerve Impulses. A Historical Sketch

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L. Brown became the unsurpassed master, made it possible to obtain from the cat gastrocnemius muscle (and later from the anterior tibialis muscle) tensions of several kilograms following rapid close-arterial injection of a few micrograms of acetylcholine. 25 /*g was effective. , if all fibres of the motor nerve became excited and a single wave of depolarisation was produced). If, a tetanus was applied for about twenty seconds after eserinisation, the contraction was not maintained, and if stimulation with single shocks was then resumed the response was reduced in comparison to that recorded before the tetanus.

Among the general conclusions of my thesis (Arch. Intern. PhysioL, 1933) was the following (p. 242): ADRENERGIC TRANSMISSION 41 'Sympathin is surely an aromatic compound. ' At Harvard, W. B. Cannon pursued his research with Arturo Rosenblueth, a Mexican physiologist, who arrived in 1930 just after we had completed the first series of experiments on sympathin. a 50 90 so1 S* lmo ,/ / ,' i 9 Duto y mo ,s>y mo coriirof] **? / 7 L/ / A / / / A • f1 f ssoo 3&o aoo nook FIG. 10. — Absorption coefficients of two perfusates from a frog heart; one perfusate obtained before, the other during stimulation of the vagosympathetic trunk.

Radicals, won for its author the Nobel Prize. In fact, the acetylation of choline is only one of the manyfold examples of chemical reactions catalyzed by coenzyme A; all these exchanges take place at the region of the terminal SH group of the molecule. THE PROGRESS OF BIOCHEMICAL RESEARCH 53 Nachmansohn * and his co-workers demonstrated the importance of ATP (adenosine 5'-triphosphate) in acetylcholine synthesis; in fact, they might have identified coenzyme A before Lipmann. They were more successful, however, in their work on the cholinesterases.

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Chemical Transmission of Nerve Impulses. A Historical Sketch by Z. M. Bacq


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