By Igor Jurisica, Dennis A. Wigle, Bill Wong
Melanoma Informatics in Post-Genomic period offers either the required technique and sensible details instruments for examining information within the box of clinical info technology. This, after all, calls for analytic instruments. these instruments are garnered by way of constructing and assessing tools and structures for the purchase, processing, and interpretation of sufferer information, aided via clinical discovery. Key demanding situations during this box comprise integrating examine and medical care, sharing information, and setting up partnerships inside of and throughout sectors of sufferer prognosis and remedy.
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Additional info for Cancer Informatics in the Post Genomic Era (Cancer Treatment and Research)
The myriad of genetic alterations and their phenotypic outputs create an exceptionally complex picture to dissect from a reductionist viewpoint. Cancer models that accurately reflect these changes are difficult to generate. It is unlikely that a single model system can faithfully reflect the whole process of cancer development and progression, and as a consequence this requires us to interpret results from model systems with caution. However, appropriate use of available model systems, with an appropriate understanding of their limitations, provides a valuable and necessary tool to study malignant transformation.
8 mg DEN/kg for 20 weeks starting at age 7-8 weeks produce lung tumors in 40-50% In Vivo Systems for Studying Cancer 31 of male Syrian hamsters. Serial studies demonstrate that most lung tumors originate from the respiratory Clara and endocrine cells (Schuller 1985). This model may be particularly appropriate for examining the chemopreventive activity of chemical agents in small cell lung cancer, a tumor originating from neuroendocrine cells in the lung. Despite the usefulness of carcinogen-induced lung cancer models, major disadvantages remain.
Most of what we know about the molecular steps involved in cancer formation comes from defined genetic manipulations in the mouse and other model organisms. In lung cancer, the lack of defined models has hampered our understanding of disease progression and potential therapeutic strategies. Such models are essential tools to facilitate the development of new therapies. Lung cancer continues to be the leading cause of cancerrelated death worldwide (Kerr 2001). Despite aggressive local and systemic therapies (Johnston, Mullen et al.
Cancer Informatics in the Post Genomic Era (Cancer Treatment and Research) by Igor Jurisica, Dennis A. Wigle, Bill Wong