By C. C. Tijssen (auth.), M. Chatel, F. Darcel, J. Pecker (eds.)
The overseas assembly on mind Oncology in Rennes used to be organised in honor of Jean Pecker, to pay tribute to his contribution to the improvement of neurological sciences and to take inventory of the present nation of information on mind tumors, a site within which the position of neurosurgery has been and may remain primordial. throughout the two-day convention, the foremost topics of mind oncology experiences, either primary and medical, have been tested: oncogenesis, tumoral markers and immunology, metabolic and analysis imaging, prognostic elements and healing thoughts. the big quantity and prime quality of participations ended in a really artificial view of present advances in learn, of which this e-book offers the necessities. we've got tried either to maintain the richness of medical exchanges which happened and to submit an exceptional many oral and poster communications. The e-book respects the association of convention periods, and hence displays the significance accorded to glial tumor reviews. this can look disproportionate given their frequency of incidence in share to overall numbers of intracranial tumor tactics, yet their gravity and quasi-total resistance to present healing tools are plentiful justification. additionally, this is often the area within which hopes of development are starting to look, and it really is turning into attainable to envisage therapy in line with lately tested basic knowledge.
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Extra info for Brain Oncology Biology, diagnosis and therapy: An international meeting on brain oncology, Rennes, France, September 4–5, 1986, held under the auspices of the Ministry of National Education, the University of Rennes and the Regional Hospital Rennes
Twelve of the 15 (80%) evaluable tumors with amplification contained DMs, while only 4 of the 16 (25%) MG's without amplification contained these structures. Polysomy 7, in contrast, characterized 7/12 (58%) evaluable MG with EGFR amplification and 9 of 17 (53%) evaluable MG without amplification of the gene, supporting the concept the EGFR amplification and polysomy 7 are unrelated in MG. DISCUSSION The most frequent chromosomal abnormalities of MG are gains of chromosome 7, losses of chromosome 10, structural abnormalities of chromosome 9 and the presence ofDMs (10).
Ki-ras, which is neither amplified nor overexpressed in gliomas, is either not involved in the process of malignant transformation of these tumors or is involved at the level of its translationnal protein product which could be deleterious due to a structural mutation. 8 metastases. 1 medulloblastoma and 1 meningioma), were sampled in sterile conditions during neurosurgical procedures and were used as a tumor bank material, stored at-80°C. The purpose ofthe present work was to study in the genomes of these brain tumors the presence of genomic sequences which could be responsible for cancer induction.
The purpose of this study was to investigate by hybridization methods the presence of such transforming genes in the genome of brain tumors, either as introduced by viruses (Herpes simplex virus, Simian Virus 40, Adenovirus type 2) or as analog to oncogenes of retroviruses. MATERIAL AND METHOD Human brain tumors A bank of90 human brain tumors have been constituted following neurosurgical excisions. During the neurosurgical procedure, the tumor tissue which was removed was immediately placed in sterile containers, frozen in liquid nitrogen and stored at -80°C until processing.
Brain Oncology Biology, diagnosis and therapy: An international meeting on brain oncology, Rennes, France, September 4–5, 1986, held under the auspices of the Ministry of National Education, the University of Rennes and the Regional Hospital Rennes by C. C. Tijssen (auth.), M. Chatel, F. Darcel, J. Pecker (eds.)