By Barbara J. Bain, David M. Clark, Irvin A. Lampert, Bridget S. Wilkins
Written by way of one of many world's prime haematologists, and 3 well known histopathologists, Bone Marrow Pathology presents a finished advisor to the prognosis of bone marrow disorder. Now in its 3rd version, the textual content has been greatly revised and rewritten to mirror the most recent advances within the box.
An super useful, up to date textual content incorporating the recent WHO category of haematopoietic malignancies
A complete textual content written with nice precision and readability of style
Incorporates a brand new part 'Problems and Pitfalls' - a different part that would relief the operating pathologist confronted with a tricky situation
An very important textual content for the haematologist, histopathologist and haematopathologist with equivalent weight given to peripheral blood, aspirate, trephine biology and really good techniques
Extensively illustrated with a few of the photos being of paraffin-embedded sections
Combines all of the options now utilized to bone marrow prognosis, together with immunocytochemistry, movement cytometery, immunohistochemistry and the diagnostic position of cytogenetic and molecular genetic analysis
Read or Download Bone Marrow Pathology (3rd Edition) PDF
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Additional resources for Bone Marrow Pathology (3rd Edition)
In assessing the morphology of megakaryocytes, it is important to remember that the megakaryocyte is a very large cell and only a cross-section of it is being examined. It is therefore not possible to determine the size or degree of nuclear lobulation of single megakaryocytes. However, by examining a large number of cells it is possible to form a judgement as to the average size of the megakaryocytes, the average degree of lobulation, and whether hypolobulated or micromegakaryocytes are present.
2) Examination of trephine biopsy sections The interpretation of trephine biopsy sections is often viewed as one of the more difﬁcult areas of surgical pathology. This is probably because the organized structure of haemopoietic tissue is not as readily apparent as that of many other tissues. However, as the preceding part of this chapter illustrates, the bone marrow is actually highly organized, with the various elements maturing in different micro-anatomical sites. Failure to recognize this and failure to identify individual categories of cell may lead to a lack of systematic analysis, with diagnoses being made only by a process of pattern recognition.
Their nuclei tend to be clearly separate, uniform in appearance and slightly oval with a single lilacstaining nucleolus. The voluminous cytoplasm contains numerous azurophilic granules which are coarser than those of megakaryocytes. Osteoclasts are not commonly seen in marrow aspirates of healthy adults but are much more often seen in aspirates from children. Histology Osteocytes, osteoblasts and osteoclasts in histological sections are identiﬁed by their position and their morphological features.
Bone Marrow Pathology (3rd Edition) by Barbara J. Bain, David M. Clark, Irvin A. Lampert, Bridget S. Wilkins