By J. Bignon
Read or Download Biochemistry, Pathology and Genetics of Pulmonary Emphysema. Proceedings of an International Symposium Held in Sassari, Italy, 27–30 April 1980 PDF
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Extra info for Biochemistry, Pathology and Genetics of Pulmonary Emphysema. Proceedings of an International Symposium Held in Sassari, Italy, 27–30 April 1980
T h a t is a v e r y i m p o r t a n t p o i n t . D r Q U I N T A R E L L I , d o y o u h a v e thoughts about that ? same Q U I N T A R E L L I (Italy). — I certainly share LADI'S v i e w , and P a u l G A L L O P and D a v i d K E I T H ' S v i e w s , that there m a y b e different elastins in a n a l o g y to c o l l a g e n s , b e c a u s e cartilage elastin does h a v e a different a m i n o acid c o m p o s i t i o n f r o m aorta elastin a n d l u n g e l a s t i n . S o it m a y w e l l b e t h a t w h e n y o u u s e , f o r i n s t a n c e , h i g h l y p u r i f i e d c a r t i l a g e e l a s t i n , this e l a s t i n p r e p a r a t i o n c o u l d e v o k e a d i f f e r e n t r e s p o n s e i n t h e animals.
T h e exact concentration of d e s m o s i n e in this standard w a s m e a s u r e d by a m i n o acid analysis with lysine as a calibration reference. ) M o l e s d e s m o s i n e in the standard were converted to μg d e s m o s i n e using a m o l e c u l a r weight of 5 2 6 daltons. Preparation of ^l-labelled desmosine A portion of the chromatographically-pure d e s m o s i n e preparation w a s labelled with 1Z5 Bolton-Hunter reagent ( I) according to m e t h o d s r e c o m m e n d e d by N e w E n g l a n d N u c l e a r .
Experimental emphysema ; Immunoelectrophoresis ; lung Relatively few studies have been published on elastin peptide or elastin antigenicity and most have involved aortic elastin rather than pulmonary [1, 6, 9, 10, 17-19]. During recent years, in our laboratory, work has attempted to define the immunogenicity of human lung elastin [2, 3]. In this brief report, I would like to summarize the results of studies of the fractionation of elastin peptides to determine which molecular fractions are most antigenic.
Biochemistry, Pathology and Genetics of Pulmonary Emphysema. Proceedings of an International Symposium Held in Sassari, Italy, 27–30 April 1980 by J. Bignon