By Iwao Ojima, Gregory D. Vite, Karl-Heinz Altmann
Describes innovative techniques within the improvement of anticancer brokers for chemotherapy. those new and interdisciplinary ways are aimed toward the improvement of tumor particular anticancer brokers whereas expanding the efficiency opposed to drug-resistant tumors. the amount contains an summary of latest paradigms for melanoma drug discovery and improvement by way of NCI, new iteration cytotoxic brokers, mechanism dependent enzyme inhibitors as anticancer brokers, anti-angiogenesis brokers, antitumor vaccines, and tumor activated prodrugs utilizing immunoconjugates of monoclonal antibodies with cytotoxic brokers.
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Extra info for Anticancer Agents: Frontiers in Cancer Chemotherapy
Ongoing trials will have to show whether these results can be confirmed in younger patients of the different risk groups. In a recently conducted Phase II clinical trial, similar encouraging results for the combination of Rituximab with standard CHOP chemotherapy in 33 previously untreated patients with high grade B-NHL were achieved. In this study 6 cycles CHOP at 3-wk intervals plus Rituximab 2 d prior to each chemotherapy course were administered. The overall response rate was 94% including 61% complete remissions and the median duration of response and time to progression had not been reached after a median observation time of 26 mo.
Et al. (1997) IDEC-C2B8 (Rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin’s lymphoma. Blood 90, 2188–2195. 19. Davis, T. , White, C. , Grillo-Lopez, A. , Velasquez, W. , Maloney, D. , et al. (1999) Single-agent monoclonal antibody efficacy in bulky non-Hodgkin’s lymphoma: results of a phase II trial of rituximab. J. Clin. Oncol. 17, 1851–1857. 20. Maloney, D. , Grillo-Lopez, A. , Bodkin, D. , White, C. , Liles, T. , et al. (1997) IDEC-C2B8: results of a phase I multiple-dose trial in patients with relapsed non-Hodgkin’s lymphoma.
In a Phase III multinational clinical trial Trastuzumab has been administered to 464 previously untreated patients with metastatic p185Her-2 positive breast cancer either as a single agent or in combination with either doxorubicin plus cyclophosphamide or paclitaxel. 9 mo (paclitaxel plus trastuzumab), respectively. The relative risk of death could be reduced by 20% at a median follow-up of 30 mo. No patient developed antibodies against Trastuzumab. Adverse side effects were generally mild to moderate in severity and occurred more frequently in the combination therapy groups.
Anticancer Agents: Frontiers in Cancer Chemotherapy by Iwao Ojima, Gregory D. Vite, Karl-Heinz Altmann