By Hwa A. Lim
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Extra info for A Global Economy without a Global Government
Other antioxidants, such as 21-aminosteroids might also be helpful. Effects of the antioxidant, 21-aminosteroid U-74006F (tirilazad mesylate), was demonstrated on the systemic and regional hemodynamics and the oxygen extraction capabilities during endotoxic shock of dogs. Compared with the endotoxin-alone group, the U-74006F-treated dogs maintained higher mean arterial pressure, cardiac index, stroke volume index, and left ventricular stroke work index and lower pulmonary vascular resistance. Authors also showed a higher fractional blood flow to mesenteric and renal beds .
At weeks 2, 3, 4, and 8, gingival index scores were significantly lower for MEG and GED groups compared to the placebo group. In addition, MEG and GED gels significantly reduced gingival bleeding responses by 8 weeks. The data from this preclinical study indicate that mercapto-alkylguanidines, topically administered, may significantly reduce experimental gingivitis in the beagles . Uveitis and Canine Cataract We know that “In oculis animus habitat (The soul dwells in the eyes),” therefore much attention must be paid to the inflammatory processes of the eye.
However, high production of H2O2 might be also beneficial due to antibacterial effect on periodontal pathogens as indicated by Hillman and Socransky . Replacement therapy may also find a practical application in the prevention and cure of certain periodontal diseases. Hydrogen peroxide-producing streptococci are invariably found in plaque taken from healthy gingiva; they are rarely found in Use of Free Radicals and Antioxidants in Inflammatory Processes of Animals 33 samples from active disease sites of patients with juvenile or refractory periodontitis.
A Global Economy without a Global Government by Hwa A. Lim